Animal research discovered that many aspects of mental and physical health which deteriorate as levels of NAD+ decline, can be restored by supplementing NMN & NR, two natural substances. Our understanding of human biology and now five years of human experience with supplementing NMN and NR showed us that many normal human processes also rely on high levels of NAD+, and using these supplements supports our bodies to maintain normal healthy functionality for longer. Both compounds have their advantages and their fans. Xtralife suggest taking both together.
The story begins with David Sinclair, proposing a radical new theory of aging, suggesting that the aging hallmarks are symptoms of epigenetic changes that occur over time, including a drop off in NAD+. Sinclair believes boosting NAD+ can slow and even reverse these changes and can be achieved by consuming NMN.
Sinclair and colleagues found that when aged mice drank NMN-infused water, their running endurance almost doubled.
Further studies have demonstrated that injecting mice with NMN preserves cognition during aging.
A study from Imai and colleagues indicates that an upsurge in NMN synthesis more than doubles the remaining lifespan of mice.
Another website for educating yourself on NMN
NAD + Deficiency Is a Common Central Pathological Factor of a Number of Diseases and Aging
NR occurs naturally in milk and in beer.
NR is well tolerated and effectively stimulates NAD+ metabolism in healthy older humans, it supports cardiovascular health, stable blood pressure and arterial health. https://pubmed.ncbi.nlm.nih.gov/29599478/
Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study
Summary of the research as at 2020.